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This sounds like a huge discrepancy (and it is), but some manufacturers fine-tune their vapes for the different nicotine levels

Public Health 31 , 402408 (2021)

As noted earlier, however, they acknowledge the impact of tax avoidance on the efficacy of state excise taxes and observe that it "points to the advantages of federal taxes." In theory, focusing on a federal tax approach could avoid some of the smuggling problems produced by large interstate tax differentials.[217] At the same time, however, it is difficult to see how a federal cigarette tax could supplant state taxes

This is certainly going to benefit the larger tobacco companies, which have the resources to get far enough into the application review process and thus wont be prioritized for enforcement, King said